Antineutrophil cytoplasmic antibody (ANCA)–connected vasculitis, including Wegener's granulomatosis and microscopic polyangiitis, is actually a multisystem autoimmune syndrome characterised by vasculitis predominantly affecting microscopic vessels and circulating autoantibodies to neutrophil cytoplasmic antigens. Renal involvement takes place in 70% of afflicted patients which is manifested as swiftly progressive glomerulonephritis with pauci-immune necrotizing, crescentic glomerulonephritis on biopsy.
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A rituximab-based program was not excellent to standard intravenous cyclophosphamide for serious ANCA-involved vasculitis. Sustained-remission shopify seo Cairns rates have been substantial in each teams, and also the learn the facts here now rituximab-dependent regimen wasn't affiliated with reductions in early critical adverse activities.
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